What is the safest way to store multiple crypto assets in the long term?

I’ve been in BTC for a while, but recently started stacking other coins (ETH, LTC, USDT, etc.). Until now, I’ve kept most of it in exchange, but obviously it’s not a wise long-term move. I know about hardware wallets like ledger and Trezor, but I also look at software/multicurrency wallets. The main things I care about are:

1. Security (2FA, encryption, no shaded background)
2. Ability to process multiple coins in one place
3. The reason I don’t get broken in the fee every time I move things is that you guys actually use the wallet setup?